Changes in High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Cholesterol Concentration in Heavy Cannabis Users: A Single-Centre Study in Cusco, Peru

Background: The effect of cannabis on cholesterol and lipid balance has been reported for decades. However, there are conflicting reports the reduction low-density lipoprotein (LDL-C) total cholesterol. purpose this study was to determine immediate changes Cannabis spp. consumption by pyrolytic route in heavy users. Methods: A cross-sectional 20 Peruvian users (mean age: 31 ± 9.5 years). inclusion criteria were males with an average weight 50–70 kg, normal BMI, having used cannabis, without association other drugs, at least one year a high frequency per week (use: 4–7 days/week). High-density (HDL-C), LDL-C, evaluated 30 120 min after administration (~0.2 g inhalation). Results: Of 12 (60%), 10 (50%), 11 (55%) had desirable cholesterol, fairly good HDL-C (40–60 mg/dL) LDL-C (100–129 values, respectively. mean basal concentration HDL-cholesterol, LDL-cholesterol 193.37 20.18 mg/dL, 60.05 6.36 129.65 14.50 HDL-cholesterol showed progressive increases participants > 60 mg/dL (10 vs. 14 participants, p < 0.001) 16 0.001), while peaked concentrations 100 (desirable cholesterol: 0 2, = 0.001). differences consumption, showing (63.25 7.68 (69.15 18.67 changed 180.95 19.3 (95%CI 172.5 189.4) (p 0.007). Conclusions: increased ingestion, partial reductions heavy-users from Cusco, Peru.